2010-11-15 Fish Oil Capsules Don't Help Atrial Fibrillation : Study- Prescription Omega-3 Supplements Don't Prevent Atrial Fibrillation Recurrences


Prescription supplements of omega-3 fatty acids do not appear to prevent recurrences of atrial fibrillation, a type of irregular heartbeat that can lead to stroke, researchers report.

"We now have definitive evidence that fish oil did not work for most patients with atrial fibrillation," says Peter R. Kowey, MD, head of cardiology at the Main Line Health Hospital outside Philadelphia.

Kowey presented the findings here at the American Heart Association's annual meeting. They were simultaneously published online by the Journal of the American Medical Association.(Read entire article)

2010-11-15 Omega-3 PUFA caps don't suppress paroxysmal AF in randomized trial



Outcomes of studies looking at whether taking omega-3 polyunsaturated fatty acids (PUFAs) in capsules can prevent various forms of atrial fibrillation (AF) have been a mixed bag. Now, one of the largest such studies in one of the commonest forms of the arrhythmia, symptomatic paroxysmal AF, suggests that taking prescription-only omega-3 PUFA capsules (Lovaza, GlaxoSmithKline) even at the fairly high dose of 4 g/day for six months doesn't cut the risk of recurrence [1].

Although the randomized, placebo-controlled trial didn't show a fish-oil effect on the primary end point—first recurrence of symptomatic AF or atrial flutter in patients with paroxysmal AF—"we did find a reduction in average ventricular rate during the first AF recurrence, a reduction in triglyceride levels at week 24 that did not occur with placebo, and increased blood levels of the omega-3 fish oils eicosapentaenoic acid and docosahexaenoic acid compared with placebo patients," according to the study's authors, led by Dr Peter R Kowey (Lankenau Institute for Medical Research, Wynnewood, PA). (Read entire article)