2010-11-08 Lung Cancer in Smokers, Nonsmokers May Be a Different Disease - Tumors in people who never smoked had more genetic abnormalities, study says


New research suggests that lung cancer in people who have never smoked may be a different disease than it is in smokers.

Scientists compared the genetic characteristics of lung cancer tumors in 30 people who never smoked to tumors in 53 smokers or former smokers.

The tumors of people who had never smoked had twice as many DNA abnormalities as people who were current or former smokers, said study author Kelsie Thu, a doctoral candidate at the British Columbia Cancer Research Centre in Vancouver.(Read entire article)

2010-11-09 Nonsmoker Lung Cancer: A Different Disease? - More and Different Genetic Changes in Nonsmoker Lung Cancers


Lung cancer in nonsmokers may be a different disease than lung cancer in cigarette smokers, new research suggests.

Accumulating evidence shows striking differences between lung tumors from patients who smoke and those who never smoked. Lung cancer in nonsmokers is more common among women -- Asian women in particular -- than lung cancer in smokers. And lung cancers in smokers tend to carry one particular mutation while those from nonsmokers tend to carry a different mutation.

Now a small study suggests that the path to getting lung cancer is much longer in nonsmokers than in smokers. Tobacco smokers may be taking a shortcut on this path -- or they may be on another path altogether. (Read entire article)