2006-11-08 Depression gene affects negative brain area

http://uk.reuters.com/article/2006/11/09/health-depression-dc-idUKN0819374520061109

A gene associated with depression and other forms of mental illness may enlarge an area of the brain that handles negative emotions, U.S. researchers reported on Wednesday.

The study is one in a number which shows that the brains of people with depression are structurally different than the brains of people who are not depressed.

Writing in the journal Biological Psychiatry, researchers from the University of Texas Southwestern Medical Center looked at a serotonin transporter gene, which has two forms, or variants -- short, or SERT-s, and long, SERT-l.(Read entire article)

2005-05-10 Depression Gene May Weaken Mood-Regulating Circuit

http://www.sciencedaily.com/releases/2005/05/050509165539.htm

A brain scan study suggests that a suspect gene may increase susceptibility to anxiety and depression* by weakening a circuit for processing negative emotion. People with the depression-linked gene variant showed less gray matter and weaker connections in the mood-regulating circuit. How well the circuit was connected accounted for nearly 30 percent of their anxious temperament, researchers at the National Institute of Health's (NIH) National Institute of Mental Health (NIMH) found. Dr. Daniel Weinberger and colleagues report on their brain imaging genetics study in the May 8, 2005 online edition of Nature Neuroscience.(Read entire article)